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Article

Presenilin-1, mutated in familial Alzheimer's disease, maintains genome stability via a γ-secretase dependent way.

DNA repair - 1 Nov 2023

Guo Xihan, Jiang Minyan, Dai Xueqin, Shen Jie, Wang Xu

Abstract excerpt

Mutations in Presenilin-1 (PS1) account for over 80 % mutations linked to familial Alzheimer's disease (AD). However, the mechanisms of action of PS1 mutations in causing familial AD are not fully understood, limiting opportunities to develop targeted disease-modifying therapies for individuals carrying PS1 mutation. To gain more comprehensive insights into the impact of PS1 mutations on genome stability, we...

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PMID: 37804602
DOI: 10.1016/j.dnarep.2023.103580

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