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Article

Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.

Acta pharmacologica Sinica - 1 Dec 2004

Luo Huan-min, Deng Hui, Xiao Fei, Gao Qin, Weng Wen, Zhang Pei-fen, Li Xiao-guang

Abstract excerpt

AIM: To investigate the pathogenesis of Abeta42 yielding and new drug targets as well as the possibility of RNA interference (RNAi) technique for treatment of Alzheimer disease (AD). METHODS: Human AD presenilin 1 (PS1) cDNA sequence was obtained from NCBI website. The three sites of RNAi action and one missense control site were selected in PS1 cDNA through online design of Ambion company. To confirm specificity...

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PMID: 15569405

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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