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Article

Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.

Acta pharmacologica Sinica - 1 Dec 2004

Luo Huan-min, Deng Hui, Xiao Fei, Gao Qin, Weng Wen, Zhang Pei-fen, Li Xiao-guang

Abstract excerpt

AIM: To investigate the pathogenesis of Abeta42 yielding and new drug targets as well as the possibility of RNA interference (RNAi) technique for treatment of Alzheimer disease (AD). METHODS: Human AD presenilin 1 (PS1) cDNA sequence was obtained from NCBI website. The three sites of RNAi action...

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PMID: 15569405

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15569405-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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