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Article

p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.

The Journal of biological chemistry - 6 Apr 2007

Dunys Julie, Kawarai Toshitaka, Sevalle Jean, Dolcini Virginia, George-Hyslop Peter St, Da Costa Cristine Alves, Checler Frédéric

Abstract excerpt

The presenilin-dependent gamma-secretase activity, which is responsible for the generation of amyloid beta-peptide, is a high molecular weight complex composed of at least four components, namely, presenilin-1 (or presenilin-2), nicastrin, Aph-1, and Pen-2. Previous data indicated that presenilins, which are thought to harbor the catalytic core of the complex, also control p53-dependent cell death. Whether the...

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Identifiers

PMID: 17276981
DOI: 10.1074/jbc.M611572200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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