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Article

H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination

10 Mar 2009

Abstract excerpt

Class switch recombination (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that allows the same variable (V) region to be expressed with any one of the downstream constant region (C) genes to encode antibodies with many different effector functions. One hypothesis for how CSR is targeted to different C region genes is that histone modifications increase accessibility and/or recruit...

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PMID: 19276123
DOI: 10.1073/pnas.0901368106

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