Article
Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2004
Li Ziqiang, Luo Zhonghui, Scharff Matthew D
Abstract excerpt
Class switch recombination (CSR) allows B cells to make effective protective antibodies. CSR involves the replacement of the mu constant region with one of the downstream constant regions by recombination between the donor and recipient switch (S) regions. Although histone H3 hyperacetylation in recipient S regions was recently reported to coincide with CSR, the relative histone H3 and H4 acetylation status of...
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