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Article

Genetic Risk Variants for Class Switching Recombination Defects in Ataxia-Telangiectasia Patients.

Journal of clinical immunology - 1 Jan 2022

Amirifar Parisa, Mehrmohamadi Mahya, Ranjouri Mohammad Reza, Akrami Seyed Mohammad, Rezaei Nima, Saberi Ali, Yazdani Reza, Abolhassani Hassan, Aghamohammadi Asghar

Abstract excerpt

BACKGROUND: Ataxia-telangiectasia (A-T) is a rare autosomal recessive disorder caused by mutations in the ataxia telangiectasia mutated (ATM) gene. A-T patients manifest considerable variability in clinical and immunological features, suggesting the presence of genetic modifying factors. A striking heterogeneity has been observed in class switching recombination (CSR) in A-T patients which cannot be explained by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34628594
DOI: 10.1007/s10875-021-01147-8
PMCID: PMC8821084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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