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Article

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.

The Journal of experimental medicine - 16 Jun 2003

Reina-San-Martin Bernardo, Difilippantonio Simone, Hanitsch Leif, Masilamani Revati F, Nussenzweig Andre, Nussenzweig Michel C

Abstract excerpt

Changes in chromatin structure induced by posttranslational modifications of histones are important regulators of genomic function. Phosphorylation of histone H2AX promotes DNA repair and helps maintain genomic stability. Although B cells lacking H2AX show impaired class switch recombination (CSR), the precise role of H2AX in CSR and somatic hypermutation (SHM) has not been defined. We show that H2AX is not...

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Share to B-Lymphocytes
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Immunoglobulin Switch Region

Share to Immunoglobulins

Share to Recombination, Genetic

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Share to Somatic Hypermutation, Immunoglobulin

Source

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Identifiers

PMID: 12810694
DOI: 10.1084/jem.20030569
PMCID: PMC2193951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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