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Article

Molecular mechanism of class switch recombination: linkage with somatic hypermutation.

Annual review of immunology - 1 Jan 2002

Honjo Tasuku, Kinoshita Kazuo, Muramatsu Masamichi

Abstract excerpt

Class switch recombination (CSR) and somatic hypermutation (SHM) have been considered to be mediated by different molecular mechanisms because both target DNAs and DNA modification products are quite distinct. However, involvement of activation-induced cytidine deaminase (AID) in both CSR and SHM has revealed that the two genetic alteration mechanisms are surprisingly similar. Accumulating data led us to propose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11861601
DOI: 10.1146/annurev.immunol.20.090501.112049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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