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Article

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

9 Mar 2009

Abstract excerpt

Expression of human tau in Caenorhabditis elegans neurons causes accumulation of aggregated tau leading to neurodegeneration and uncoordinated movement. We used this model of human tauopathy disorders to screen for genes required for tau neurotoxicity. Recessive loss-of-function mutations in the sut-2 locus suppress the Unc phenotype, tau aggregation and neurodegenerative changes caused by human tau. We cloned...

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PMID: 19273536
DOI: 10.1093/hmg/ddp099

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