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Article

Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation.

Cell reports - 7 Aug 2014

Huang Yunpeng, Wu Zhihao, Cao Yu, Lang Minglin, Lu Bingwei, Zhou Bing

Abstract excerpt

Tau hyperphosphorylation is thought to underlie tauopathy. Working in a Drosophila tauopathy model expressing a human Tau mutant (hTauR406W, or Tau(∗)), we show that zinc contributes to the development of Tau toxicity through two independent actions: by increasing Tau phosphorylation and, more significantly, by directly binding to Tau. Elimination of zinc binding through amino acid substitution of Cys residues...

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Identifiers

PMID: 25066125
DOI: 10.1016/j.celrep.2014.06.047
PMCID: PMC4306234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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