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Article

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

Neurobiology of disease - 1 Jan 2021

Kow Rebecca L, Strovas Timothy J, McMillan Pamela J, Jacobi Ashley M, Behlke Mark A, Saxton Aleen D, Latimer Caitlin S, Keene C Dirk, Kraemer Brian C

Abstract excerpt

Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 suppress tau-mediated neurotoxicity in C. elegans neurons, cultured human cells, and mouse brain, while loss of PABPN1 had the opposite effect (Wheeler et al., 2019)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33184027
DOI: 10.1016/j.nbd.2020.105148
PMCID: PMC8092974

Genes

TOE1
PABPN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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