Article

Loss of Aly/ALYREF Suppresses Toxicity in Both Tau and TDP-43 Models of Neurodegeneration

2021-10-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Neurodegenerative diseases with tau pathology, or tauopathies, include Alzheimer’s Disease and related dementia disorders. Previous work has shown that loss of the poly(A) RNA-binding protein gene sut2/MSUT2 strongly suppressed tauopathy in C. elegans, human cell culture, and mouse models of tauopathy. However, the mechanism of suppression is still unclear. Recen...

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Literature Corpus work: a0ff684a-dcc2-5d77-93e3-b8dd3e7249c7
DOI: 10.21203/rs.3.rs-954125/v1

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