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Article

SUT-1 enables tau-induced neurotoxicity in C. elegans.

Human molecular genetics - 15 Aug 2007

Kraemer Brian C, Schellenberg Gerard D

Abstract excerpt

We previously reported a transgenic Caenorhabditis elegans model for tauopathies in which expression of human tau in neurons caused insoluble phosphorylated tau accumulation, neurodegeneration and uncoordinated movement (Unc). To identify genes participating in tau neurotoxicity, we conducted a forward genetic screen for mutations that ameliorate tau-induced uncoordination. The recessive mutation sut-1(bk79)...

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Identifiers

PMID: 17576746
DOI: 10.1093/hmg/ddm143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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