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Article

Sut-6/NIPP1 modulates tau toxicity

31 Mar 2023

Abstract excerpt

Neurodegenerative diseases exhibiting the pathological accumulation of tau such as Alzheimer's disease and related disorders still have no disease-modifying treatments and the molecular mechanisms of neurodegeneration remain unclear. To discover additional suppressor of tauopathy (sut) genes that mediate or modulate the toxicity of pathological tau, we performed a classical genetic screen using a tau transgenic...

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PMID: 37000013
DOI: 10.1093/hmg/ddad049

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