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Article

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment.

Pharmacogenetics and genomics - 1 Jun 2008

Tzvetkov Mladen Vassilev, Brockmöller Jürgen, Roots Ivar, Kirchheiner Julia

Abstract excerpt

OBJECTIVE: Genetic variability within the serotoninergic system may predict the response to antidepressant drugs. Several polymorphisms in the gene coding for the brain-specific tryptophan hydroxylase (TPH2) have been associated with susceptibility to psychiatric diseases. In this study, we analyzed the correlation between TPH2 polymorphisms and response to antidepressant drugs. METHODS: The study included 182...

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Source

Identifiers

PMID: 18496129
DOI: 10.1097/FPC.0b013e3282fb02cb

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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