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Article

Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674.

Circulation research - 27 Mar 2009

Lancel Steve, Zhang Jingmei, Evangelista Alicia, Trucillo Mario P, Tong Xiaoyong, Siwik Deborah A, Cohen Richard A, Colucci Wilson S

Abstract excerpt

Nitroxyl (HNO) exerts inotropic and lusitropic effects in myocardium, in part via activation of SERCA (sarcoplasmic reticulum calcium ATPase). To elucidate the molecular mechanism, adult rat ventricular myocytes were exposed to HNO derived from Angeli's salt. HNO increased the maximal rate of thapsigargin-sensitive Ca2+ uptake mediated by SERCA in sarcoplasmic vesicles and caused reversible oxidative modification...

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Source

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Identifiers

PMID: 19265039
DOI: 10.1161/CIRCRESAHA.108.188441
PMCID: PMC3046805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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