Article

Nitric Oxide modulates spontaneous Ca <sup>2+</sup> release and ventricular arrhythmias during β-adrenergic signalling through <i>S</i> -nitrosylation of Calcium/Calmodulin dependent kinase II

2023-08-25

Abstract excerpt

<h4>Rationale</h4> Nitric oxide (NO) has been identified as a signalling molecule generated during β-adrenergic receptor (AR) stimulation in the heart. Furthermore, a role for NO in triggering spontaneous Ca 2+ release via S -nitrosylation of Ca 2+ /calmodulin kinase II delta (CaMKIIδ) is emerging. NO donors are routinely used clinically for their cardioprotective effects in the heart, but it is unknown how NO...

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Literature Corpus work: ea76274c-6dbf-5a96-82f4-522cc7aa65f5
DOI: 10.1101/2023.08.23.554546

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