Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

S-nitrosylation inhibits pannexin 1 channel function.

The Journal of biological chemistry - 16 Nov 2012

Lohman Alexander W, Weaver Janelle L, Billaud Marie, Sandilos Joanna K, Griffiths Rachael, Straub Adam C, Penuela Silvia, Leitinger Norbert, Laird Dale W, Bayliss Douglas A, Isakson Brant E

Abstract excerpt

S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity. Using the biotin switch assay, we found that application of the NO donor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dithiothreitol
Share to Glutathione

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nitric Oxide

Share to Nitric Oxide Donors

Share to Nitro Compounds

Share to Oxadiazoles

Share to Quaternary Ammonium Compounds

Share to Quinoxalines

Source

Open in PubMed Open full text

Identifiers

PMID: 23033481
DOI: 10.1074/jbc.M112.397976
PMCID: PMC3501028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

S-nitrosylation inhibits pannexin 1 channel function.PMID 23033481Read ↗

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.Semantic proximity Read ↗

Is it go or NO go for S-nitrosylation modification-based therapies of cystic fibrosis transmembrane regulator trafficking?Semantic proximity Read ↗

Differential activation of mouse and human Panx1 channel variantsSemantic proximity Read ↗

Human spermatozoa contain multiple targets for protein S‐nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide?Semantic proximity Read ↗

The Pannexin1 membrane channel: distinct conformations and functions.Semantic proximity Read ↗

S-nitrosothiols signaling in cystic fibrosis airways.Semantic proximity Read ↗

Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1.Semantic proximity Read ↗

N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1.Semantic proximity Read ↗

Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus.Semantic proximity Read ↗

Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation.Semantic proximity Read ↗

Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.Semantic proximity Read ↗

S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.