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Article

S-nitrosylation inhibits pannexin 1 channel function.

The Journal of biological chemistry - 16 Nov 2012

Lohman Alexander W, Weaver Janelle L, Billaud Marie, Sandilos Joanna K, Griffiths Rachael, Straub Adam C, Penuela Silvia, Leitinger Norbert, Laird Dale W, Bayliss Douglas A, Isakson Brant E

Abstract excerpt

S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modif...

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Identifiers

PMID: 23033481
DOI: 10.1074/jbc.M112.397976
PMCID: PMC3501028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23033481-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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