Article

Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction

2024-12-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Recent reports suggest increased myocardial iNOS expression leads to excessive protein s -nitrosylation, contributing to the pathophysiology of HFpEF. However, the relationship between NO bioavailability, dynamic regulation of protein s -nitrosylation by trans- and de-nitrosylases, and HFpEF pathophysiology has not been elucidated. Here, we provide novel insights into the...

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Literature Corpus work: c9570e38-b8bc-5f27-a3a6-2ed7c820dbf9
DOI: 10.1101/2024.12.20.629549

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