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Article

S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy.

Circulation research - 9 Oct 2015

Irie Tomoya, Sips Patrick Y, Kai Shinichi, Kida Kotaro, Ikeda Kohei, Hirai Shuichi, Moazzami Kasra, Jiramongkolchai Pawina, Bloch Donald B, Doulias Paschalis-Thomas, Armoundas Antonis A, Kaneki Masao, Ischiropoulos Harry, Kranias Evangelia, Bloch Kenneth D, Stamler Jonathan S, Ichinose Fumito

Abstract excerpt

RATIONALE: The regulation of calcium (Ca(2+)) homeostasis by β-adrenergic receptor (βAR) activation provides the essential underpinnings of sympathetic regulation of myocardial function, as well as a basis for understanding molecular events that result in hypertrophic signaling and heart failure. Sympathetic stimulation of the βAR not only induces protein phosphorylation but also activates nitric oxide-dependent...

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Source

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Identifiers

PMID: 26259881
DOI: 10.1161/CIRCRESAHA.115.307157
PMCID: PMC4600453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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