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Article

Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2012

Crassous Pierre-Antoine, Couloubaly Samba, Huang Can, Zhou Zongmin, Baskaran Padmamalini, Kim David D, Papapetropoulos Andreas, Fioramonti Xavier, Durán Walter N, Beuve Annie

Abstract excerpt

Nitric oxide (NO) by activating soluble guanylyl cyclase (sGC) is involved in vascular homeostasis via induction of smooth muscle relaxation. In cardiovascular diseases (CVDs), endothelial dysfunction with altered vascular reactivity is mostly attributed to decreased NO bioavailability via oxidative stress. However, in several studies, relaxation to NO is only partially restored by exogenous NO donors, suggesting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22730391
DOI: 10.1152/ajpheart.00138.2012
PMCID: PMC3468472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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