Article
Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation.
Circulation research - 17 Jul 2009
Figtree Gemma A, Liu Chia-Chi, Bibert Stephanie, Hamilton Elisha J, Garcia Alvaro, White Caroline N, Chia Karin K M, Cornelius Flemming, Geering Kaethi, Rasmussen Helge H
Abstract excerpt
Angiotensin II (Ang II) inhibits the cardiac sarcolemmal Na(+)-K(+) pump via protein kinase (PK)C-dependent activation of NADPH oxidase. We examined whether this is mediated by oxidative modification of the pump subunits. We detected glutathionylation of beta(1), but not alpha(1), subunits in rabbit ventricular myocytes at baseline. beta(1) Subunit glutathionylation was increased by peroxynitrite (ONOO(-)),...
Topics
- Adenosine Triphosphatases
- Angiotensin II
- Animals
- Cation Transport Proteins
- Cell Adhesion Molecules, Neuronal
- Cysteine
- Glutaredoxins
- Glutathione
- Humans
- Kidney
- Kinetics
- Male
- Mutation
- Myocytes, Cardiac