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Article

S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide.

Nature medicine - 1 Nov 2004

Adachi Takeshi, Weisbrod Robert M, Pimentel David R, Ying Jia, Sharov Victor S, Schöneich Christian, Cohen Richard A

Abstract excerpt

Nitric oxide (NO) physiologically stimulates the sarco/endoplasmic reticulum calcium (Ca(2+)) ATPase (SERCA) to decrease intracellular Ca(2+) concentration and relax cardiac, skeletal and vascular smooth muscle. Here, we show that NO-derived peroxynitrite (ONOO(-)) directly increases SERCA activity by S-glutathiolation and that this modification of SERCA is blocked by irreversible oxidation of the relevant...

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Identifiers

PMID: 15489859
DOI: 10.1038/nm1119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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