Article
Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice.
Circulation - 22 Dec 2020
Goodman Jena B, Qin Fuzhong, Morgan Robert J, Chambers Jordan M, Croteau Dominique, Siwik Deborah A, Hobai Ion, Panagia Marcello, Luptak Ivan, Bachschmid Markus, Tong XiaoYong, Pimentel David R, Cohen Richard A, Colucci Wilson S
Abstract excerpt
BACKGROUND: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in response to reactive oxygen species, we hypothesized that SERCA oxidation at C674 would modulate the effects of reactive oxygen species on...
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