Article
rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population.
The American journal of gastroenterology - 1 Mar 2009
Glas Jürgen, Seiderer Julia, Pasciuto Giulia, Tillack Cornelia, Diegelmann Julia, Pfennig Simone, Konrad Astrid, Schmechel Silke, Wetzke Martin, Török Helga-Paula, Stallhofer Johannes, Jürgens Matthias, Griga Thomas, Klein Wolfram, Epplen Jörg T, Schiemann Uwe, Mussack Thomas, Lohse Peter, Göke Burkhard, Ochsenkühn Thomas, Folwaczny Matthias, Müller-Myhsok Bertram, Brand Stephan
Abstract excerpt
OBJECTIVES: Recently, a North American genome-wide association study identified three novel gene variants in PHOX2B, NCF4, and FAM92B as well as one single nucleotide polymorphisms (SNP; rs224136) in the intergenic region on chromosome 10q21.1 as being associated with Crohn's disease (CD). However, their influence on European CD patients as well as ulcerative colitis (UC) is unknown. Therefore we aimed to...
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