Article
IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.
The American journal of gastroenterology - 1 Dec 2007
Roberts Rebecca L, Gearry Richard B, Hollis-Moffatt Jade E, Miller Allison L, Reid Julia, Abkevich Victor, Timms Kirsten M, Gutin Alexander, Lanchbury Jerry S, Merriman Tony R, Barclay Murray L, Kennedy Martin A
Abstract excerpt
OBJECTIVE: Recently, separate genome-wide association analyses have identified nonsynonymous SNPs in IL23R and ATG16L1 (rs11209026; c1142G>A, R381Q, and rs2241880; c1338A>G, T300A, respectively) as strong candidate susceptibility factors for Crohn's disease (CD) in whites. The aim of our study was to test whether these SNPs are associated with CD in a population-based cohort of New Zealand Caucasian inflammatory...
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