Article
Contribution of the NOD1/CARD4 insertion/deletion polymorphism +32656 to inflammatory bowel disease in Northern Europe.
Inflammatory bowel diseases - 1 Jul 2007
Van Limbergen J, Russell R K, Nimmo E R, Törkvist L, Lees C W, Drummond H E, Smith L, Anderson N H, Gillett P M, McGrogan P, Hassan K, Weaver L T, Bisset W M, Mahdi G, Arnott I D, Sjöqvist U, Lördal M, Farrington S M, Dunlop M G, Wilson D C, Satsangi J
Abstract excerpt
BACKGROUND: NOD1/CARD4 and NOD2/CARD15 are both intracellular pattern-recognition receptors. The NOD1/CARD4 gene lies within a previously described inflammatory bowel disease (IBD) locus (7p14). An association has been suggested between the NOD1/CARD4+32656 deletion*1 variant of a complex deletion*1/insertion*2 polymorphism and IBD in 1 recent study in Europe. Our aim was to assess the influence of...
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