Article
PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites.
PloS one - 1 Jan 2012
Glas Jürgen, Seiderer Julia, Czamara Darina, Pasciuto Giulia, Diegelmann Julia, Wetzke Martin, Olszak Torsten, Wolf Christiane, Müller-Myhsok Bertram, Balschun Tobias, Achkar Jean-Paul, Kamboh M Ilyas, Franke Andre, Duerr Richard H, Brand Stephan
Abstract excerpt
BACKGROUND: Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (IBD) and to elucidate genotypic and phenotypic interactions with other IBD genes. METHODOLOGY/PRINCIPAL FINDINGS: A total of 7073 patients and...
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