Article
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
PloS one - 8 Aug 2007
Franke Andre, Hampe Jochen, Rosenstiel Philip, Becker Christian, Wagner Florian, Häsler Robert, Little Randall D, Huse Klaus, Ruether Andreas, Balschun Tobias, Wittig Michael, Elsharawy Abdou, Mayr Gabriele, Albrecht Mario, Prescott Natalie J, Onnie Clive M, Fournier Hélène, Keith Tim, Radelof Uwe, Platzer Matthias, Mathew Christopher G, Stoll Monika, Krawczak Michael, Nürnberg Peter, Schreiber Stefan
Abstract excerpt
Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder. Although recent studies have successfully identified CD-associated genetic variants, these susceptibility loci explain only a fraction of the heritability of the disease. Here, we report on a multi-stage genome-wide scan of 393 German CD cases and 399 controls. Among the 116,161 single-nucleotide polymorphisms...
Topics
- Calcium-Binding Proteins
- Chromosome Mapping
- Colitis, Ulcerative
- Crohn Disease
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Haplotypes