Article
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Nature - 23 Apr 2009
Cantó Carles, Gerhart-Hines Zachary, Feige Jerome N, Lagouge Marie, Noriega Lilia, Milne Jill C, Elliott Peter J, Puigserver Pere, Auwerx Johan
Abstract excerpt
AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary scale in eukaryotes that senses changes in the intracellular AMP/ATP ratio. Recent evidence indicated an important role for AMPK in the therapeutic benefits of metformin, thiazolidinediones and exercise, which form the cornerstones of the clinical management of type 2 diabetes and associated metabolic disorders. In...
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