Interactions Among mTORC, AMPK and SIRT A Computational Model for Cell Energy Balance and Metabolism

Abstract excerpt

<title>Abstract</title> <p>BackgroundCells adapt their metabolism and activities in response to signals from their surroundings, and this ability is essential for their survival in the face of perturbations. In tissues a deficit of these mechanisms is commonly associated with cellular aging and diseases, such as cardiovascular disease, cancer, immune system decline, and neurological pathologies. Several proteins...

Topics

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• Aminoimidazole Carboxamide
• AMP-Activated Protein Kinases
• Autophagy in Disease and Therapy
• Forkhead Box Protein O1
• Forkhead Box Protein O3
• Histone Deacetylase Inhibitors Research
• Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
• Sirtuin 1

Identifiers and source

Literature Corpus work

a4cdf80d-0063-557b-9381-aa2169bd1124

DOI

10.21203/rs.3.rs-122671/v1