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Article

Controlling SIRT1 expression by microRNAs in health and metabolic disease

5 Aug 2010

Abstract excerpt

SIRT1 is a NAD+-dependent deacetylase implicated in longevity and diverse physiological processes. SIRT1, as a key mediator of beneficial effects of caloric restriction, regulates lipid and glucose metabolism by deacetylating metabolic regulators, as well as histones, in response to nutritional deprivation. Here we discuss how SIRT1 levels are regulated by microRNAs (miRs) which are emerging as important...

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PMID: 20689156
DOI: 10.18632/aging.100184

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