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Article

AMPK, insulin resistance, and the metabolic syndrome

30 Jun 2013

Abstract excerpt

Insulin resistance (IR) and hyperinsulinemia are hallmarks of the metabolic syndrome, as are central adiposity, dyslipidemia, and a predisposition to type 2 diabetes, atherosclerotic cardiovascular disease, hypertension, and certain cancers. Regular exercise and calorie restriction have long been known to increase insulin sensitivity and decrease the prevalence of these disorders. The subsequent identification of...

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PMID: 23863634
DOI: 10.1172/jci67227

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