Article
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.
Physiological reviews - 1 Jul 2012
Nogueiras Ruben, Habegger Kirk M, Chaudhary Nilika, Finan Brian, Banks Alexander S, Dietrich Marcelo O, Horvath Tamas L, Sinclair David A, Pfluger Paul T, Tschöp Matthias H
Abstract excerpt
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria, respectively. Both are activated by high NAD(+) levels, a condition...
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