Article
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Cell metabolism - 6 Apr 2011
Bai Péter, Cantó Carles, Oudart Hugues, Brunyánszki Attila, Cen Yana, Thomas Charles, Yamamoto Hiroyasu, Huber Aline, Kiss Borbála, Houtkooper Riekelt H, Schoonjans Kristina, Schreiber Valérie, Sauve Anthony A, Menissier-de Murcia Josiane, Auwerx Johan
Abstract excerpt
SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. Here we show that the deletion of the poly(ADP-ribose) polymerase-1 (PARP-1) gene, encoding a major...
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