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Regulation of mitochondrial biogenesis

9 Jun 2010

Abstract excerpt

Although it is well established that physical activity increases mitochondrial content in muscle, the molecular mechanisms underlying this process have only recently been elucidated. Mitochondrial dysfunction is an important component of different diseases associated with aging, such as Type 2 diabetes and Alzheimer's disease. PGC-1alpha (peroxisome-proliferator-activated receptor gamma co-activator-1alpha) is a...

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PMID: 20533901
DOI: 10.1042/bse0470069

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