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Article

The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2009

Nukaya Manabu, Moran Susan, Bradfield Christopher A

Abstract excerpt

The aryl hydrocarbon receptor (AHR) plays a central role in 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) hepatotoxicity, regulation of xenobiotic metabolism, and hepatovascular development. Each of these processes appears to be dependent on binding of the AHR to dioxin- responsive elements (DREs) within the genome. The Cyp1a1 and Cyp1a2 loci represent linked genes thought to play important roles in AHR biology....

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Source

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Identifiers

PMID: 19261855
DOI: 10.1073/pnas.0809613106
PMCID: PMC2651201

Genes

AHR

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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