Article
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 1996
Schmidt J V, Su G H, Reddy J K, Simon M C, Bradfield C A
Abstract excerpt
The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. In an effort to gain insight into the physiological role of the AHR and to develop models useful in r...
Topics
- Alleles
- Animals
- Cell Line
- Cytochrome P-450 Enzyme System
- Female
- Gene Targeting
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Phenotype
- Polychlorinated Dibenzodioxins
- Receptors, Aryl Hydrocarbon