Article
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 1996
Schmidt J V, Su G H, Reddy J K, Simon M C, Bradfield C A
Abstract excerpt
The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. In an effort to gain insight into the physiological role of the AHR and to develop models useful in risk assessment, gene targeting was used to inactivate the murine Ahr gene by homologous recombination. Ahr-/- mice are...
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