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Article

A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia.

The Journal of biological chemistry - 13 Apr 2007

Rivera Steven P, Wang Feng, Saarikoski Sirkku T, Taylor Robert T, Chapman Brett, Zhang Ruixue, Hankinson Oliver

Abstract excerpt

Cytochrome P4502S1 (CYP2S1) is expressed at high levels in epithelial tissues and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) via the aryl hydrocarbon receptor (AHR). Transcriptional initiation of mouse Cyp2s1 was found to occur at three regions, approximately 198, 102, and 22 nucleotides from the translational initiation codon. Approximately 400 nucleotides upstream of its translational...

Read the complete abstract on PubMed

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Share to Cell Hypoxia
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dimerization

Share to Gene Expression Regulation, Enzymologic

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 17277313
DOI: 10.1074/jbc.M609617200

Genes

ARNT
AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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