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Article

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

Toxicology and applied pharmacology - 15 Oct 2013

Harrill Joshua A, Hukkanen Renee R, Lawson Marie, Martin Greg, Gilger Brian, Soldatow Valerie, Lecluyse Edward L, Budinsky Robert A, Rowlands J Craig, Thomas Russell S

Abstract excerpt

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor which plays a role in the development of multiple tissues and is activated by a large number of ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In order to examine the roles of the AHR in both normal biological development and response to environmental chemicals, an AHR knockout (AHR-KO) rat model was created and...

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Source

Identifiers

PMID: 23859880
DOI: 10.1016/j.taap.2013.06.024

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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