Article
Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor.
The Journal of biological chemistry - 16 May 2003
Bunger Maureen K, Moran Susan M, Glover Edward, Thomae Tami L, Lahvis Garet P, Lin Bernice C, Bradfield Christopher A
Abstract excerpt
The Ah receptor (AHR) mediates the metabolic adaptation to a number of planar aromatic chemicals. Essential steps in this adaptive mechanism include AHR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the Ah receptor nuclear translocator, and binding of this heterodimeric transcription factor to dioxin-responsive elements (DREs) upstream of promoters that regulate...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cell Nucleus
- Cells, Cultured
- Dose-Response Relationship, Drug
- Drug Resistance
- Fibroblasts
- Gene Targeting
- Genetic Vectors