Article
Organization and function of a dioxin-responsive enhancer.
The Journal of biological chemistry - 15 Jun 1990
Fisher J M, Wu L, Denison M S, Whitlock J P
Abstract excerpt
The dioxin-responsive enhancer upstream of the CYP1A1 gene contains four copies of the recognition motif for the liganded Ah receptor. The results of deletion analyses, linker-scanning analyses, and the analysis of individual enhancer subdomains reveal that each copy of the motif contributes to the response of the enhancer to 2,3,7,8-tetrachlorodibenzo-p-dioxin. In the context of the dioxin-responsive enhancer, a...
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