Article
Organization and function of a dioxin-responsive enhancer.
The Journal of biological chemistry - 15 Jun 1990
Fisher J M, Wu L, Denison M S, Whitlock J P
Abstract excerpt
The dioxin-responsive enhancer upstream of the CYP1A1 gene contains four copies of the recognition motif for the liganded Ah receptor. The results of deletion analyses, linker-scanning analyses, and the analysis of individual enhancer subdomains reveal that each copy of the motif contributes to t...
Topics
- Animals
- Base Sequence
- Chromosome Deletion
- Cytochrome P-450 Enzyme System
- Dioxins
- Enhancer Elements, Genetic
- Escherichia coli
- Gene Expression
- Genes
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Plasmids
- Polychlorinated Dibenzodioxins
- Receptors, Aryl Hydrocarbon
- Receptors, Drug
- Restriction Mapping