Article
Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.
Biology of reproduction - 1 Mar 2010
Ohsako Seiichiroh, Fukuzawa Noriho, Ishimura Ryuta, Kawakami Takashige, Wu Qing, Nagano Reiko, Zaha Hiroko, Sone Hideko, Yonemoto Junzo, Tohyama Chiharu
Abstract excerpt
TCDD (2,3,7,8-tetrachlorodebenzo-p-dioxin) requires the presence of the aryl hydrocarbon receptor (Ahr) gene for its toxic effects, such as reproductive disorders in male offspring of maternally exposed rats and mice. To study the involvement of the Ahr gene in producing the toxic phenotype with respect to testicular development, we administered a relatively high dose of TCDD to mice with three different...
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