Article
Design and validation of new genotypic tools for easy and reliable estimation of HIV tropism before using CCR5 antagonists.
The Journal of antimicrobial chemotherapy - 1 May 2009
Poveda Eva, Seclén Eduardo, González María del Mar, García Federico, Chueca Natalia, Aguilera Antonio, Rodríguez Jose Javier, González-Lahoz Juan, Soriano Vincent
Abstract excerpt
BACKGROUND: Genotypic tools may allow easier and less expensive estimation of HIV tropism before prescription of CCR5 antagonists compared with the Trofile assay (Monogram Biosciences, South San Francisco, CA, USA). METHODS: Paired genotypic and Trofile results were compared in plasma samples derived from the maraviroc expanded access programme (EAP) in Europe. A new genotypic approach was built to improve the...
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