Article
[Methods for determination of HIV tropism and their clinical use].
Enfermedades infecciosas y microbiologia clinica - 1 Dec 2011
Gutiérrez Félix, Rodríguez Juan Carlos, García Federico, Poveda Eva
Abstract excerpt
Determination of HIV-1 tropism is mandatory before using CCR5 antagonists in clinical practice. One drug of this class, maraviroc, has been approved for the treatment of HIV infection. The phenotypic assay, TrofileTM, was clinically validated in the clinical development program of maraviroc and has been widely used to select candidates for maraviroc therapy. Phenotypic tests, however, have the disadvantage of...
Topics
- Algorithms
- Anti-HIV Agents
- CCR5 Receptor Antagonists
- Clinical Trials as Topic
- Cyclohexanes
- Europe
- Genes, env
- Genotype
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV Infections