Article
Evaluation of the genotypic prediction of HIV-1 coreceptor use versus a phenotypic assay and correlation with the virological response to maraviroc: the ANRS GenoTropism study.
Antimicrobial agents and chemotherapy - 1 Aug 2010
Recordon-Pinson Patricia, Soulié Cathia, Flandre Philippe, Descamps Diane, Lazrek Mouna, Charpentier Charlotte, Montes Brigitte, Trabaud Mary-Anne, Cottalorda Jacqueline, Schneider Véronique, Morand-Joubert Laurence, Tamalet Catherine, Desbois Delphine, Macé Muriel, Ferré Virginie, Vabret Astrid, Ruffault Annick, Pallier Coralie, Raymond Stéphanie, Izopet Jacques, Reynes Jacques, Marcelin Anne-Geneviève, Masquelier Bernard
Abstract excerpt
Genotypic algorithms for prediction of HIV-1 coreceptor usage need to be evaluated in a clinical setting. We aimed at studying (i) the correlation of genotypic prediction of coreceptor use in comparison with a phenotypic assay and (ii) the relationship between genotypic prediction of coreceptor use at baseline and the virological response (VR) to a therapy including maraviroc (MVC). Antiretroviral-experienced...
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