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Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Feb 2009

Maekawa K, Yoshimura T, Saito Y, Fujimura Y, Aohara F, Emoto C, Iwasaki K, Hanioka N, Narimatsu S, Niwa T, Sawada J

Abstract excerpt

1. To assess the substrate-dependent effects of the low-activity allele of human CYP3A4, CYP3A4*16 (Thr185Ser), a recombinant wild-type (CYP3A4.1) or variant (CYP3A4.16) protein was co-expressed with human NADPH-P450 reductase in Sf21 insect cells using a baculovirus-insect cell system. 2. The holo-CYP3A4 protein level of CYP3A4.16 in insect microsomes was slightly higher than that of CYP3A4.1, while no...

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PMID: 19255940
DOI: 10.1080/00498250802617746

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