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CYP3A416 and CYP3A418 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2010

Maekawa Keiko, Harakawa Noriko, Yoshimura Takuya, Kim Su-Ryang, Fujimura Yoshiyuki, Aohara Fumika, Sai Kimie, Katori Noriko, Tohkin Masahiro, Naito Mikihiko, Hasegawa Ryuichi, Okuda Haruhiro, Sawada Jun-ichi, Niwa Takuro, Saito Yoshiro

Abstract excerpt

CYP3A4, the major form of cytochrome P450 (P450) expressed in the adult human liver, is involved in the metabolism of approximately 50% of commonly prescribed drugs. Several genetic polymorphisms in CYP3A4 are known to affect its catalytic activity and to contribute in part to interindividual differences in the pharmacokinetics and pharmacodynamics of CYP3A4 substrate drugs. In this study, catalytic activities of...

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PMID: 20847137
DOI: 10.1124/dmd.110.034140

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