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Functional Analysis of Wild-Type and 27 CYP3A4 Variants on Dronedarone Metabolism In vitro.

Current drug metabolism - 1 Jan 2022

Wang Chen-Chen, Lan Tian

Abstract excerpt

BACKGROUND: Cytochrome P450 (P450) is the largest family of enzymatic proteins in the human liver, and its features have been studied in physiology, medicine, biotechnology, and phytoremediation. OBJECTIVE: The aim of this study was to assess the catalytic activities of 28 human CYP3A4 alleles by using dronedarone as a probe drug in vitro, including 7 novel alleles recently found in the Han Chinese population....

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PMID: 35702776
DOI: 10.2174/1389200223666220613153917

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