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Article

Evaluation of Recombinant CYP3A4 Variants on the Metabolism of Oxycodone In Vitro.

Chemical research in toxicology - 18 Jan 2021

Cai Yaoyao, Lin Qianmeng, Jin Zhousheng, Xia Fangfang, Ye Yingchao, Xia Yun, Papadimos Thomas J, Wang Quanguang, Hu Guoxin, Cai Jianping, Chen Limei

Abstract excerpt

Cytochrome P450 3A4 is a highly polymorphic enzyme and metabolizes approximately 40%-60% of therapeutic drugs. Its genetic polymorphism may significantly affect the expression and function of CYP3A4 resulting in alterations of the pharmacokinetics and pharmacodynamics of the CYP3A4-mediated drugs. The purpose of this study was to evaluate the catalytic activities of 30 CYP3A4 nonsynonymous variants and wild type...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33393779
DOI: 10.1021/acs.chemrestox.0c00361

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